2 Paradoxically, ACE2 is protective in the cardiovascular system, and SARS-CoV-1 S protein promotes lung injury by decreasing the level of ACE2 in the infected lungs. Vascular endothelium can be infected by SARS-CoV-2, 1 which triggers mitochondrial reactive oxygen species production and glycolytic shift. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells.
0 Comments
Leave a Reply. |